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A TREATMENT FOR ADULTS WITH TYPE 2 DIABETES MELLITUS, IN ADDITION TO DIET AND EXERCISE

STARTING THE ONGLYZA DIALOGUE WITH YOUR PATIENTS

IMPORTANT TALKING POINTS AND RESOURCES FOR YOUR PATIENTS WITH TYPE 2 DIABETES MELLITUS

Managing patients with type 2 diabetes mellitus requires more than just the right prescription. It also requires ongoing patient discussion and support. This section contains important topics to discuss with patients for whom ONGLYZA may be appropriate and links to additional resources for you and your patients.

1

Discuss whether ONGLYZA is appropriate for your patients

  • ONGLYZA is appropriate for patients who need A1C reductions in addition to diet and exercise. ONGLYZA is a dipeptidyl peptidase-4 (DPP-4) inhibitor that can be prescribed alone or in addition to:
    • Metformin
    • Insulin
    • Sulfonylurea
    • TZD
    • Metformin + Sulfonylurea
  • Patients should be informed of the potential risks and benefits of ONGLYZA and of alternative modes of therapy. Talk to patients about the importance of adherence to dietary instructions, regular physical activity, periodic blood glucose monitoring and A1C testing, recognition and management of hypoglycemia and hyperglycemia. During periods of stress such as fever, trauma, infection, or surgery, medication requirements may change and patients should be advised to seek medical advice promptly
  • Patients should be informed that acute pancreatitis has been reported during postmarketing use of ONGLYZA. Before initiating ONGLYZA, question patients about other risk factors for pancreatitis, such as a history of pancreatitis, alcoholism, gallstones, or hypertriglyceridemia. Patients should also be informed that persistent severe abdominal pain, sometimes radiating to the back, which may or may not be accompanied by vomiting, is the hallmark symptom of acute pancreatitis. Instruct patients to promptly discontinue ONGLYZA and contact their healthcare provider if persistent severe abdominal pain occurs
  • Patients should be informed that serious allergic reactions, such as angioedema, anaphylaxis, and exfoliative skin conditions, have been reported during postmarketing use of ONGLYZA. If symptoms of these allergic reactions occur, patients must stop taking ONGLYZA and seek medical advice promptly

2

Discuss the recommended dosing and administration instructions

  • The recommended dosage of ONGLYZA is 2.5 mg or 5 mg once daily, taken regardless of meals
  • ONGLYZA tablets must be swallowed whole and never crushed, cut, or chewed
  • Patients should be informed that if they miss a dose they should take the next dose as prescribed. Instruct patients not to take an extra dose the next day

3

Hypoglycemia

  • When ONGLYZA was used in combination with a sulfonylurea or with insulin, medications known to cause hypoglycemia, the incidence of confirmed hypoglycemia was increased over that of placebo used in combination with a sulfonylurea or with insulin. Therefore, a lower dose of the insulin secretagogue or insulin may be required to minimize the risk of hypoglycemia when used in combination with ONGLYZA

4

Encourage patients to access money-saving* offers and helpful patient support resources

  • Affordability is an important factor for diabetes patients and their health care professionals. Explore money-saving offers for eligible* patients who have been prescribed ONGLYZA

FIND MONEY-SAVING OFFERS »

  • Share helpful resources, listed below, to provide educational and treatment support for your patients

*Subject to eligibility. Restrictions apply. Not available for government-insured patients.

DOWNLOADABLE RESOURCES

Help reinforce the patient dialogue with these downloadable patient support resources:

ONGLYZA PATIENT BROCHURE—explains how ONGLYZA may help lower blood sugar with descriptions of how ONGLYZA works in the body, and the results of two clinical studies. It also shows how patients may be eligible to save money on their prescriptions of ONGLYZA, and the support available through the Fit2Me™ program that helps patients design appropriate meal plans and activities that they enjoy

MANAGING YOUR TYPE 2 DIABETES SHEET—diet and lifestyle suggestions to help your patients manage their type 2 diabetes, such as taking a short walk after meals or drinking one less soda per day. Includes descriptions of basic terms such as A1C, and a goal-setting guide

WHAT ARE YOUR NUMBERS TELLING YOU? BROCHURE—descriptions and illustrations to help patients understand type 2 diabetes, and how measurements such as A1C, FPG, and PPG are used to track their blood glucose levels. It also describes other health care specialties that you may recommend such as ophthalmologists, dietitians, and podiatrists

WHAT ARE YOUR NUMBERS TELLING YOU? BROCHURE IN SPANISH—the same brochure described above to give to your Spanish-speaking patients

PATIENT SUPPORT SITES

Help your adult type 2 diabetes patients design their support program, their way.

Fit2Me is:

  • A free, comprehensive online diet and lifestyle support program designed to help you and your patient make diet and lifestyle choices that fit into their type 2 diabetes mellitus treatment plan
  • A comprehensive program built for your patient, using the foods they love, the activities they like to do, and the motivational support they choose

VISIT FIT2ME.COM »

Your patients want to learn about their type 2 diabetes mellitus. You can help them understand.

Health Journey Support is:

  • An online health library to share with your patients, containing videos and printable brochures, including information on type 2 diabetes mellitus
  • A source of educational materials across AstraZeneca therapeutic areas, from diagnosis to treatment and wellness. Helping patients through the health journey every step of the way

VISIT HEALTHJOURNEYSUPPORT.COM »