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A TREATMENT FOR ADULTS WITH TYPE 2 DIABETES MELLITUS, IN ADDITION TO DIET AND EXERCISE

DOSING & ADMINISTRATION

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CONVENIENT, ONCE-DAILY DOSING

Rx for ONGLYZA® (saxagliptin) 5 mg PO once daily
Dosing
ONCE-DAILY DOSING
Recommended dose taken
once daily regardless of meals
5 mg
OR
2.5 mg

Tablets shown are not actual sizes.

Tablets must be swallowed whole and not be split or cut.1

2.5 mg recommended starting dose for moderate or severe renal impairment or ESRD requiring hemodialysis (eGFR <45mL/min/1.73 m2), or coadministration with strong CYP3A4/5 inhibitors
  • Single, one-step dose adjustment in patients with moderate to severe renal impairment or with ESRD requiring hemodialysis from ONGLYZA 5 mg to ONGLYZA 2.5 mg. ONGLYZA should be administered following hemodialysis. ONGLYZA has not been studied in patients undergoing peritoneal dialysis1
  • Because ketoconazole, a strong CYP3A4/5 inhibitor, increased saxagliptin exposure, the dose of ONGLYZA should be limited to 2.5 mg when coadministered with a strong CYP3A4/5 inhibitor (eg, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin)
  • No dose adjustment is required based on gender, race, weight, or hepatic impairment1

Assessment of renal function is recommended prior to initiation of ONGLYZA and periodically thereafter.1


INDIVIDUALIZING DIABETES MELLITUS TREATMENT FOR YOUR PATIENTS

When treating your patients with type 2 diabetes mellitus, consider ONGLYZA as an add-on to commonly used oral agents such as metformin to help your patients get where they need to be.

 

Drug Interactions

Strong CYP3A4/5 inhibitors (eg, ketoconazole): Coadministration with ONGLYZA significantly increases saxagliptin concentrations. Recommend limiting ONGLYZA dosage to 2.5 mg once daily.

Use in Specific Populations

In patients with moderate or severe renal impairment, or end-stage renal disease (eGFR <45 mL/min/1.73 m2), recommended dosage is 2.5 mg once daily regardless of meals. ONGLYZA should be administered following hemodialysis. Assess renal function before starting ONGLYZA and periodically thereafter.